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Semaglutide Is the Better-Evidenced Agent Several randomized trials conducted between 2021 and 2025 showed semaglutide 1.0–2.4mg weekly produces roughly 10–15% weight loss in PCOS patients over 6–12 months, with parallel improvements in menstrual cycle frequency, testosterone, sex hormone-binding globulin (SHBG), and HOMA-IR (a marker of insulin resistance)
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Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7–36) amide in type I diabetic patients
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